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Today, the U.S. Food and Drug Administration is issuing a Safety Communication to inform patients and health care providers that devices claiming to clean, disinfect or sanitize continuous positive airway pressure (CPAP) devices or accessories (such as masks, tubing, headgear) using ozone gas or ultraviolet (UV) light are not legally marketed for this use by the FDA in the U.S., and as such, their safety and effectiveness for use with CPAP devices and accessories is unknown. CPAP devices are often prescribed for home use to patients with obstructive sleep apnea, a condition where an individual’s airway becomes blocked during sleep causing breathing to intermittently stop and start. CPAP devices use air pressure to keep airways open during sleep.

To ensure the safe and effective cleaning of CPAP devices and accessories, the FDA is recommending that consumers and health care providers follow the cleaning instructions provided by the CPAP’s manufacturer, which normally include regular cleaning with soap and water.

“The FDA has identified several manufacturers that are marketing ozone gas or UV light-based products claiming to clean, disinfect or sanitize CPAP devices and accessories in the home,” said William H. Maisel, M.D., M.P.H, director of the Office of Product Evaluation and Quality in the FDA’s Center for Devices and Radiological Health. “Exposure to high levels of ozone gas may worsen a patients’ existing chronic respiratory diseases or increase the chance of a respiratory infection. UV light-based products could cause burns, eye damage or increase the risk of skin cancer due to over exposure. The FDA has contacted manufacturers of products making these claims and asked them to submit data demonstrating their safety and effectiveness.”

The FDA has received 11 reports from 2017-2019 from patients experiencing cough, difficult breathing, nasal irritation, headaches, asthma attacks and other breathing complaints when ozone gas-based products were used to clean, sanitize or disinfect CPAP devices and accessories. The FDA has not received any adverse event reports for UV light products claiming to clean, disinfect or sanitize CPAP devices and accessories.

Ozone is a gas that can be used to kill harmful bacteria. However, for ozone to be effective in killing harmful bacteria, it must be present at a concentration far greater than what is considered safe for humans. Although products claiming to clean, disinfect or sanitize CPAP devices that use ozone gas claim that they are designed to keep ozone gas inside the machine and its accessories, leaks can occur at tubing connections, filters or through containers used to house CPAP accessories. When leaks occur, ozone gas in the room where the devices are used may temporarily rise to unsafe levels especially if the room is small or not well ventilated.

Additionally, if the CPAP machine or accessories are used without first allowing fresh air to circulate through the entire CPAP system to remove any remaining ozone gas, this could lead to someone inhaling ozone gas, which could cause breathing problems.

Direct exposure to UV light may cause injury depending on its wavelength, intensity and exposure time. Additionally, the UV light may not be able to penetrate all components of CPAP devices and accessories, like the plastic tubing, masks and connectors, which could lead to inadequately disinfected components that may be unsafe for people to reuse.

While these devices claiming to clean, sanitize or disinfect CPAP machines and accessories have not been FDA cleared or approved for marketing in the U.S., the FDA conducted its own preliminary lab testing on several of those illegally marketed products. The testing demonstrated ozone-using disinfection devices generated ambient levels of ozone above limits considered safe for human exposure. Ozone levels were also high in CPAP machines and tubing even after waiting the amount of time recommended by the ozone-based device manufacturer after a cleaning cycle. The FDA’s studies also showed the power of the UV light and time during which CPAP masks and accessories were exposed to this light varied considerably among UV cleaners. If CPAP components are exposed to insufficiently strong UV light or processed for an insufficient amount of time, the CPAP components could be inadequately disinfected leading to safety and performance issues.

The FDA has contacted manufacturers of the ozone gas and UV light products that claim to clean, sanitize or disinfect CPAP devices and accessories. Each manufacturer was informed that based on their product’s intended use and technological characteristics, FDA review and clearance or approval is needed and that data would need to be provided to demonstrate safety and effectiveness.

The FDA will continue to monitor reports of adverse events associated with the use of ozone gas or UV-based CPAP devices that claim to clean, sanitize or disinfect CPAP devices and accessories and update the public should new information become available.

The FDA encourages individuals to report adverse events related to the use these devices to the FDA.

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

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Inquiries

Related Information

Additional Information

This page provides information on compounds recognized as ozone-depleting substances () under the Montreal Protocol.

The ODS are split into two groups under the Clean Air Act: Class I ODS, such as (CFCs), and Class II ODS, such as (HCFCs).

For each ODS, this page provides the compound’s atmospheric lifetime, O (ODP), (GWP), and Chemistry Abstract Service (CAS) registry numbers.

Information on acceptable ODS alternatives (e.g., hydrofluorocarbons) is available through EPA’s Significant New Alternatives Policy (SNAP) Program.

Class I ODS

Class I ODS are divided into eight groups.

• Class I ODS listed in Groups 1 through 5 are identified in Title VI of the Clean Air Act.
• Class I ODS listed in Groups 6 and 7, methyl bromide and hydrobromofluorocarbons, are identified in EPA's Accelerated Phaseout final rule.
• Class I ODS listed in Group 8, chlorobromomethane, is identified in EPA's Chlorobromomethane Phaseout final rule.

Why are there multiple values given for the ODPs and GWPs?

The numbers in the “ODP1” column are from the Montreal Protocol. Some numbers have been updated as per amendments to the Protocol.

Data in the “ODP2” column come from WMO’s Scientific Assessment of Ozone Depletion: 2010.¹ ODP values listed are semi-empirical and can be found in Table 5-1 of the document.

The numbers in the “GWP1” column represent global warming potentials over a 100-year time horizon. The numbers are from the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report: Climate Change 2007 (AR4).² The values listed are for direct radiative forcing and can be found in Table 2.14 of the “Physical Science Basis” contribution to the report.

The numbers in the “GWP2” column also represent global warming potentials over a 100-year time horizon. The numbers are from the IPCC Fifth Assessment Report: Climate Change 2014 (AR5). The values listed are for direct radiative forcing and can be found in Table 8.A.1 of the “Physical Science Basis” contribution to the report.³

References

1. WMO (World Meteorological Organization), 2011: Scientific Assessment of Ozone Depletion: 2010. Global Ozone Research and Monitoring Project—Report No. 52, Geneva, Switzerland, 516 pp.
2. IPCC, 2007: Climate Change 2007: The Physical Science Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change [Solomon, S., D. Qin, M. Manning, Z. Chen, M. Marquis, K.B. Averyt, M. Tignor and H.L. Miller (eds.)]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA, 996 pp.
3. IPCC, 2013: Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change [Stocker, T.F., D. Qin, G.-K. Plattner, M. Tignor, S.K. Allen, J. Boschung, A. Nauels, Y. Xia, V. Bex and P.M. Midgley (eds.)]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA, 1535 pp.

Class II ODS

Why are there multiple values given for the ODPs and GWPs?

The numbers in the “ODP1” column are from the Montreal Protocol. Some numbers have been updated as per amendments to the Protocol.

Ozone Laptops & Desktops Driver Download For Windows 8

Data in the “ODP2” column come from WMO’s Scientific Assessment of Ozone Depletion: 2010.¹ ODP values listed are semi-empirical and can be found in Table 5-1 of the document.

The numbers in the “GWP1” column represent global warming potentials over a 100-year time horizon. The numbers are from the IPCC Fourth Assessment Report: Climate Change 2007 (AR4).² The values listed are for direct radiative forcing and can be found in Table 2.14 of the “Physical Science Basis” contribution to the report.

The numbers in the “GWP2” column also represent global warming potentials over a 100-year time horizon. The numbers are from the IPCC Fifth Assessment Report: Climate Change 2014 (AR5). The values listed are for direct radiative forcing and can be found in Table 8.A.1 of the “Physical Science Basis: contribution to the report.³

References

Ozone Laptops & Desktops Driver Download For Windows 10

1. WMO (World Meteorological Organization), 2011: Scientific Assessment of Ozone Depletion: 2010. Global Ozone Research and Monitoring Project—Report No. 52, Geneva, Switzerland, 516 pp.
2. IPCC, 2007: Climate Change 2007: The Physical Science Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change [Solomon, S., D. Qin, M. Manning, Z. Chen, M. Marquis, K.B. Averyt, M. Tignor and H.L. Miller (eds.)]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA, 996 pp.
3. IPCC, 2013: Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change [Stocker, T.F., D. Qin, G.-K. Plattner, M. Tignor, S.K. Allen, J. Boschung, A. Nauels, Y. Xia, V. Bex and P.M. Midgley (eds.)]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA, 1535 pp.